Abstract Purpose: Azanucleoside DNA methyltransferase (DNMT) inhibitors are currently
approved by the US Food and Drug Administration for treatment of myelodysplastic …

Hypermethylation of CpG islands near gene promoter regions is associated with
transcriptional inactivation and represents an important mechanism of gene silencing in …

Methylation of DNA is a biochemical modification that can influence gene expression and is
involved in inactivating one of the two X chromosomes in women. Evidence that has …

Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …

Hypomethylating agents (HMAs), azacitidine and decitabine, are standards of care in higher-
risk myelodysplastic syndromes and in acute myeloid leukemia patients ineligible for …