Although intratumoral heterogeneity has been established in pediatric central nervous
system tumors, epigenomic alterations at the cell type level have largely remained …

Structural variation heavily influences the molecular landscape of cancer, in part by
impacting DNA methylation-mediated transcriptional regulation. Here, using multi-omic …

Abstract Background Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains
understudied in pediatric central nervous system (CNS) tumors. 5hmC is abundant in the …

Background: Neuroblastoma is the most common extracranial solid malignancy in infancy
and childhood, but the biological factors involved in its development and progression are …

PURPOSE Whole-genome profiles of the epigenetic modification 5-hydroxymethylcytosine
(5-hmC) are robust diagnostic biomarkers in adult patients with cancer. We investigated if 5 …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Pediatric brain tumors are the leading cancer-related cause of death in children and
adolescents in the United States, affecting on average 1 in 2000 children per year. Recent …

Glioblastomas exhibit widespread molecular alterations including a highly distorted
epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine …

CpG island hypermethylation has been recognized as an alternative mechanism for tumor
suppressor gene inactivation. In this study, we performed methylation-specific PCR (MSP) to …

Neuroblastoma (NB) pathogenesis has been reported to be closely associated with
numerous genetic alterations. However, underlying DNA methylation patterns have not been …