ABSTRACT Background Trimethylamine-N-oxide (TMAO), a diet-derived and gut microbiota–
related metabolite, is associated with cardiovascular disease (CVD). However, major dietary …

Objectives Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link
between red meat intake and poor cardiometabolic health. We investigated whether gut …

TMAO is elevated in individuals with cardiometabolic diseases, but it is unknown whether
the metabolite is a biomarker of concern in healthy individuals. We conducted a cross …

ABSTRACT Background Trimethylamine N-oxide (TMAO), a compound derived from diet
and metabolism by the gut microbiome, has been associated with several chronic diseases …

ABSTRACT Background Trimethylamine N-oxide (TMAO), a diet-derived, gut microbial-host
cometabolite, has been linked to cardiometabolic diseases. However, the relations remain …

Background Trimethylamine‐N‐oxide (TMAO) is a small molecule derived from the
metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease …

Context Several studies suggest a relationship between trimethylamine N-oxide (TMAO)
concentrations and increased cardiometabolic risk, but findings are controversial. Objective …

Scope Trimethylamine‐N‐oxide (TMAO), a metabolite linked to the gut microbiota, is
associated with excess risk of heart disease. We hypothesized that (i) TMAO response to …

Background Trimethylamine N‐oxide (TMAO) is a gut microbiota‐dependent metabolite of
dietary choline, L‐carnitine, and phosphatidylcholine‐rich foods. On the basis of …

Aims Carnitine and choline are major nutrient precursors for gut microbiota-dependent
generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed …