Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice

H Shi, P Li, H Zhou, Z Nie, J Zhang, X Sui, J Guo… - Brain Research, 2022 - Elsevier
Acute hypobaric hypoxia (AHH) exposure causes altitude mountain sickness (AMS) and life-
threatening high altitude cerebral edema (HACE). Despite decades of research, the role of …

[HTML][HTML] Neurological, neurophysiological, psychological and psychiatric effects of high altitude and hypoxia

M Pun, M Falla, G Strapazzon, K Hüfner - Frontiers in Physiology, 2023 - frontiersin.org
Mental disorders show a prevalence of 30%–40% in the general population (Steel et al.,
2014), and neurological symptoms such as headache or dizziness are among the most …

Multimodal analysis of the effects of dexamethasone on high-altitude cerebral oedema: protocol for a pilot study

O Fisher, RA Benson, S Wayte, PK Kimani… - Trials, 2019 - Springer
Background Acute mountain sickness (AMS) is a cluster of symptoms that commonly occur
in those ascending to high altitudes. Symptoms can include headaches, nausea, insomnia …

Investigating Sea-Level Brain Predictors for Acute Mountain Sickness: A Multimodal MRI Study before and after High-Altitude Exposure

W Zhang, J Feng, W Liu, S Zhang… - American Journal …, 2024 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Acute mountain sickness is a series of brain-centered
symptoms that occur when rapidly ascending to high altitude. Predicting acute mountain …

High altitude cerebral edema and acute mountain sickness: a pathophysiology update

PH Hackett - Hypoxia: into the next millennium, 1999 - Springer
The diagnosis, treatment and prevention of high altitude cerebral edema (HACE) are fairly
well established. The major unresolved issues are 1) the pathophysiology, 2) the individual …

What role does the blood brain barrier play in acute mountain sickness?

A Baneke - Travel medicine and infectious disease, 2010 - Elsevier
As high altitude travel increases, acute mountain sickness (AMS) and life threatening high
altitude cerebral oedema (HACE) are becoming more prevalent. Acute mountain sickness …

Regional differences in the cerebral blood flow velocity response to hypobaric hypoxia at high altitudes

B Feddersen, P Neupane… - Journal of Cerebral …, 2015 - journals.sagepub.com
Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time
allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to …

Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

Y Li, C Li, T Luo, T Yue, W Xiao, L Yang… - Journal of …, 2023 - Taylor & Francis
With the increasing of altitude activities from low-altitude people, the study of high altitude
cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness …

Lessons from altitude: cerebral perfusion insights and their potential translational clinical significance

C Imray - Experimental Physiology, 2016 - Wiley Online Library
New Findings What is the topic of this review? The long‐held assumption that transcranial
Doppler middle cerebral artery velocity is a surrogate for cerebral blood flow has been …

Near-infrared spectroscopy in the assessment of cerebral oxygenation at high altitude

CHE Imray, NJ Barnett, S Walsh… - Wilderness & …, 1998 - journals.sagepub.com
Hypoxia plays a key role in the pathogenesis of acute mountain sickness (AMS), but
individual susceptibility is variable and cerebral symptoms do not always correlate with …