From a fertilised egg to a mature organism, cells divide and accumulate epigenetic
information, which is faithfully passed on to daughter cells. DNA methylation consolidates …

DNA methylation is an essential epigenetic modification for mammalian embryonic
development and biology. The DNA methylation pattern across the genome, together with …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …

The role of intermediate methylation states in DNA is unclear. Here, to comprehensively
identify regions of intermediate methylation and their quantitative relationship with gene …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

A long path, initiated more than 40 years ago, has led to a deeper understanding of the
complexity of gene regulation in eukaryotic genomes. In addition to genetic mechanisms, the …