[HTML][HTML] DNA methylation, its mediators and genome integrity

H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

Active turnover of DNA methylation during cell fate decisions

A Parry, S Rulands, W Reik - Nature Reviews Genetics, 2021 - nature.com
DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …

DNA methylation presents distinct binding sites for human transcription factors

S Hu, J Wan, Y Su, Q Song, Y Zeng, HN Nguyen… - elife, 2013 - elifesciences.org
DNA methylation, especially CpG methylation at promoter regions, has been generally
considered as a potent epigenetic modification that prohibits transcription factor (TF) …

Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation

J Wan, VF Oliver, G Wang, H Zhu, DJ Zack, SL Merbs… - BMC genomics, 2015 - Springer
Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …

Exposing the DNA methylome iceberg

MN Ndlovu, H Denis, F Fuks - Trends in biochemical sciences, 2011 - cell.com
DNA methylation was the first epigenetic modification discovered. Until recently,
comprehensive coverage of the composition and distribution of methylated cytosines across …

[HTML][HTML] The DNA methylome

M Pelizzola, JR Ecker - FEBS letters, 2011 - Elsevier
Methylation of cytosines is a pervasive feature of eukaryotic genomes and an important
epigenetic layer that is fundamental for cellular differentiation processes and control of …

DNA methylation at the crossroads of gene and environment interactions

PP Law, ML Holland - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …

Genomic DNA methylation: the mark and its mediators

RJ Klose, AP Bird - Trends in biochemical sciences, 2006 - cell.com
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

DNA methyltransferases: facts, clues, mysteries

C Brenner, F Fuks - DNA Methylation: Basic Mechanisms, 2006 - Springer
DNA methylation plays a pivotal role during development in mammals and is central to
transcriptional silencing. The DNA methyltransferases (DNMTs) are responsible for the …

DNA methylation and demethylation in mammals

Z Chen, AD Riggs - Journal of Biological Chemistry, 2011 - ASBMB
Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …