DNA methylation is an important epigenetic modification that is known to be altered in
rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter …

Objectives Epigenetics can influence disease susceptibility and severity. While DNA
methylation of individual genes has been explored in autoimmunity, no unbiased systematic …

Objective Rheumatoid arthritis synovial fibroblasts (RASFs) are phenotypically activated and
aggressive. We undertook this study to investigate whether the intrinsic activation of RASFs …

Rheumatoid arthritis (RA) is a long-term autoimmune disease of unknown etiology that leads
to progressive joint destruction and ultimately to disability. RA affects as much as 1% of the …

Aim: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no
studies have interrogated this epigenetic modification in early disease. Following recent …

Changes to the DNA methylome have been described in patients with rheumatoid arthritis
(RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte …

Rheumatoid arthritis (RA) is a complex chronic systematic disease with progressive
destruction of the joints by invasive synoviocytes. To characterize the key regulators …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

Epigenetics can contribute to pathogenic mechanisms in autoimmunity, and we recently
identified an imprinted DNA methylation pattern in rheumatoid arthritis (RA) fibroblast-like …

Objective Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly
targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to …