Perturbed epigenetic landscape and deregulated microRNA networks are central to the
permanent activation and aggressiveness of synovial fibroblasts in rheumatoid arthritis …

Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with
heterogeneous presentation and complex aetiology where DNA methylation changes are …

Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to
a crosstalk between genetic predisposition and environmental factors. Both variants of …

Rheumatoid arthritis (RA) is a complex condition that displays heterogeneity in disease
severity and response to standard treatments between patients. Failure rates for …

Knee osteoarthritis (OA) is a leading cause of chronic disability worldwide, but no diagnostic
or prognostic biomarkers are available. Increasing evidence supports epigenetic …

Juvenile idiopathic arthritis (JIA) is the most common autoimmune rheumatic disease of
childhood. We recently showed that DNA methylation at the gene encoding the pro …

Objective Aberrant activation of synovial fibroblasts is a key determinant in the pathogenesis
of rheumatoid arthritis (RA). The aims of this study were to produce a map of gene …

Objectives Increasing evidence suggests an epigenetic contribution to the pathogenesis of
autoimmune diseases, including primary Sjögren's Syndrome (pSS). The aim of this study …

Epigenetic anomalies are emerging as key pathogenic features of rheumatoid arthritis (RA).
The effect of epigenetics in RA ranges from contributing to complex disease mechanisms to …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the
world's population. The etiology of RA remains unknown. It is considered to occur in the …