In order to discover new inhibitors of the DNA methyltransferase 3A/3L complex, we used a
medium-throughput nonradioactive screen on a random collection of 1120 small organic …

In humans, the most common epigenetic DNA modification is methylation of the 5-carbon of
cytosines, predominantly in CpG dinucleotides. DNA methylation is an important epigenetic …

DNA methylation is the most studied epigenetic event. Since the methylation profile of the
genome is widely modified in cancer cells, DNA methyltransferases are the target of new …

The genome contains genetic and epigenetic information. While the genome provides the
blueprint for the manufacture of all the proteins required to create a living thing, the …

The DNA methyltransferase (DNMT) enzyme family consists of four members with diverse
functions and represents one of the most promising targets for the development of novel …

DNA methylation is an epigenetic mechanism mediated by a family of proteins called DNA
methyltransferases (DNMTs). The misregulation of the covalent modification of DNA through …

DNA methylation, an epigenetic modification regulating gene expression, is a promising
target in cancer. In an effort to identify new non nucleosidic inhibitors of DNA …

Hypermethylation of CpG regions by human DNA methyltransferase 1 (DNMT1) silences
tumor-suppression genes, and inhibition of DNMT1 can reactivate silenced genes. The 5 …

DNA methylation is an important epigenetic modification catalyzed by DNA
methyltransferases (DNMTs). Abnormal expression of endogenous DNMTs in human …

The DNA methyltransferases (DNMTs) found in mammals include DNMT1, DNMT3A, and
DNMT3B and are attractive targets in cancer chemotherapy. DNMT1 was the first among the …