Numerous murine (mouse and rat) models of polycystic kidney disease (PKD) have been
described in which the mutant phenotype results from a spontaneous mutation or …

Major advances in the understanding of the genetics and pathogenesis of autosomal
dominant polycystic kidney disease have occurred within the past year. The proteins …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, which encode polycystin-1 and polycystin-2, respectively. Rodent models are …

New insights into the molecular pathophysiology of polycystic kidney disease. Polycystic
kidney diseases are characterized by the progressive expansion of multiple cystic lesions …

Autosomal dominant polycystic kidney disease, a leading cause of end-stage renal disease
in adults, is characterized by progressive focal cyst formation in the kidney. Embryonic …

The most common inherited form of human polycystic kidney disease (PKD), autosomal
dominant PKD (ADPKD), is a leading cause of chronic renal failure, but has a variable …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutation of one of two
genes: PKD1 (16p13. 3) or PKD2 (4q13–23). PKD1 accounts for∼ 85% of pedigrees and is …

Polycystic kidney disease (PKD) is a hereditary disorder with abnormal cellular proliferation,
fluid accumulation in numerous cysts, remodeling of extracellular matrix, inflammation, and …

Autosomal dominant polycystic kidney disease (ADPKD), primarily due to PKD1 or PKD2
mutations, causes progressive kidney cyst development and kidney failure. There is …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the commonest inherited
human disorders yet remains relatively unknown to the wider medical, scientific and public …