CYP3A isozymes participate in the metabolism of 45–60% of currently used drugs and of a
variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A …

The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …

Many studies have attempted to explain the interindividual variability observed in drug
metabolism by assessing the impact of SNPs in genes implicated in drug absorption …

The ontogenesis of CYP1A proteins was investigated in a human liver bank composed of
fetal, neonatal and adult samples. In immunoblots, a polyclonal antibody raised against rat …

Cytochrome P450s are oxidative metabolic enzymes that play critical roles in the
biotransformation of endogenous compounds and xenobiotics. The expression and activity …

Cytochromes P450 3A (CYP3A) and P-glycoprotein (P-gp) are mainly located in enterocytes
and hepatocytes. The CYP3A/P-gp system contributes to the first-pass metabolism of many …

Correct dosing of drugs in neonates, infants and children is hampered by a general lack of
knowledge about drug disposition in this population. Suggested methods to improve our …

Cytochrome P450 enzymes of subfamily 3A account for as much as 30 and 80% of total
P450 content in liver and intestine, respectively [1, 2]. Their abundant expression, as well as …

CYP3A4 is the most important drug metabolizing enzyme in adult humans because of its
prominent expression in liver and gut and because of its broad substrate specificity, which …

Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of
clinically important drugs (eg, clozapine, tacrine, tizanidine, and theophylline), a number of …