Soluble oligomers of the amyloid-β (Aβ) peptide are thought to play a key role in the
pathophysiology of Alzheimer's disease (AD). Recently, we reported that synthetic Aβ …

Background β-Amyloid precursor protein (APP) has been reported to play a role in the
outgrowth of neurites from cultured neurons. Both cell-surface APP and its soluble …

An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of
synaptic connections within cortical neuronal microcircuits. Recently, soluble amyloid β …

Mutations in β-amyloid (Aβ) precursor protein (APP) cause familial Alzheimer's disease (AD)
probably by enhancing Aβ peptides production from APP. An antibody targeting Aβ …

Using microarray technology we studied the genome-wide gene expression profiles in the
frontal cortex of APPswe/PS1dE9 mice and age and sex-matched littermates at the age of 2 …

In the non-amyloidogenic pathway the α-secretase cleaves the amyloid precursor protein
(APP) within the sequence of Aβ-peptides and precludes their formation. In addition, α …

Mice carrying mutated human APPswe and PS1 (A246E) transgenes (A/P mice) show age-
dependent memory impairment in hippocampus-dependent tasks. Moreover, the mice show …

The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's
disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue …

Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles
associated with chronic inflammation. APPswe/PS1dE9 is an AD mouse model bearing …