Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the
integrative molecular mechanisms of the organism, based on interconnections of the …

Melatonin (N-acetyl-5-methoxytryptamine) was first purified and characterized from the
bovine pineal gland extract by Aron Lerner and co-workers in 1958. Since then, a plethora of …

Melatonin is an indoleamine with the chemical name N-acetyl-5-methoxytryptamine and is
found in animals, plants, and bacteria. It has endocrine properties in both animals and …

Melatonin is a ubiquitous molecule in nature, being locally synthesized in several cells and
tissues, besides being a hormone that is centrally produced in the pineal gland of …

This review summarizes the metabolism, secretion, regulation and sites of action of
melatonin. An updated description of the melatonin receptors, including their signal …

Highlights•Pathways controlling melatonin secretion are complex.•There are various causes
of melatonin disturbance.•Evaluation of melatonin secretion clinically requires long time …

This book presents the basic concepts of melatonin action at a cellular level to immediate
applications in clinical medicine. It examines how the perception of melatonin's …

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in
various species. In vertebrates, melatonin is produced predominantly by the pineal gland …

Melatonin is a hormone produced mainly by the pineal gland in most vertebrate species,
including humans. Recent metabolic, receptor and functional studies created a picture of the …