Previously published comparative functional genomic data sets from primates using frozen
tissue samples, including many data sets from our own group, were often collected and …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

The modification of DNA by methylation is an important epigenetic mechanism that affects
the spatial and temporal regulation of gene expression. Methylation patterns have been …

DNA methylation is an epigenetic modification, influenced by both genetic and
environmental variation, that plays a key role in transcriptional regulation and many …

Background Single-cell transcriptome and single-cell methylome technologies have become
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …

DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Epigenetic mechanisms traditionally have been studied in the domains of development and
disease, but they may also play important roles in ecological and evolutionary processes. In …

There is increasing interest in understanding the potential for epigenetic factors to contribute
to phenotypic diversity in evolutionary biology. One well studied epigenetic mechanism is …

DNA methylation is a key epigenetic modification in the vertebrate genomes known to be
involved in biological processes such as regulation of gene expression, DNA structure and …