Abstract Methyl CpG-binding protein 2 (MeCP2), the mutated protein in Rett syndrome
(RTT), is a crucial chromatin-modifying and gene-regulatory protein that has two main …

The identification of mutations in the gene encoding methyl CpG binding protein 2 (MeCP2)
in Rett syndrome represents a major advance in the field. The current model predicts that …

The X-linked methyl-CpG-binding protein 2 gene (MECP2) encodes a protein that links DNA
methylation to transcriptional repression mediated by histone deacetylases. Mutations in …

Me CP 2 is a chromatin‐associated protein that is mutated in Rett syndrome. Its methyl‐CpG‐
binding domain interacts with DNA containing methylated cytosine, but other modes of …

Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the X-linked
gene MECP2 (methyl-CpG-binding protein 2). Two decades of research have fostered the …

Publisher Summary This chapter introduces Rett Syndrome (RTT), which is a
neurodevelopmental disorder representing one of the most frequent causes of severe …

Rett syndrome, a neurodevelopmental disorder caused by mutations in the X-linked gene
encoding methyl-CpG-binding protein 2 (MeCP2), is a leading cause of mental retardation …

DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …

Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and a chromatin-
binding protein involved in neuronal development and maturation. Loss-of-function …