HPA axis genes implicated in glucocorticoid regulation play an important role in regulating
the physiological impact of social and environmental stress, and have become a focal point …

Background Epigenetic mechanisms may play a major role in the biological embedding of
early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release …

Early-life stress (ELS) is known to be associated with an increased risk of neuropsychiatric
and cardiometabolic disease in later life. One of the potential mechanisms underpinning this …

Objective: Understandings of the biological mechanisms underpinning posttrauma
responses are limited. This pilot study aimed to expand research in this area by examining …

Genome‐wide association studies (GWAS) have identified numerous disease‐associated
variants; however, these variants have a minor effect on disease and explain only a small …

DNA methylation of the FKBP5 gene is assumed to alter FKBP5 expression and hence the
synthesis of the FK506 binding protein 51, a central element of a genomic negative …

Importance Depressive disorders arise from a combination of genetic and environmental risk
factors. Epigenetic disruption provides a plausible mechanism through which gene …

Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment
for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD …

DNA methylation, which is modulated by both genetic factors and environmental exposures,
may offer a unique opportunity to discover novel biomarkers of disease-related brain …

There has been a limited number of systematic reviews conducted to summarize the
overview of the relationship between DNA methylation and depression, and to critically …