Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

DNA methyltransferases (DNMTs) establish and maintain DNA methylation patterns at
specific regions of the genome, thereby contributing to gene regulation. It is becoming …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …

Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …

Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …

The molecular pathways that regulate gain and loss of DNA methylation during mammalian
development need to be tightly balanced to maintain a physiological equilibrium. Here we …

Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …