DNA methylation is the most widely-studied epigenetic modification, playing a critical role in
the regulation of gene expression. Dysregulation of DNA methylation is implicated in the …

DNA methylation has long been considered a very stable DNA modification in mammals that
could only be removed by replication in the absence of remethylation–that is, by mere …

DNA methylation is a covalent modification of DNA that plays an important role in setting
gene expression programs during development. Recent evidence suggests that changes in …

DNA methylation is a well-studied epigenetic modification that has key roles in regulating
gene expression, maintaining genome integrity, and determining cell fate. Precisely how …

Although essentially all cells of a mammalian organism contain the same genetic
information they may differ dramatically in form and function. This cellular differentiation is …

DNA methylation is generally limited to CpG doublets located at the gene promoter with an
involvement in gene silencing. Surprisingly, two recent papers showed an extensive …

DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

Cells encounter a multitude of external and internal stress-causing agents that can ultimately
lead to DNA damage, mutations and disease. A cascade of signaling events counters these …

DNA methylation in mammals is essential for numerous biological functions, such as
ensuring chromosomal stability, genomic imprinting, and X-chromosome inactivation …