Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease
Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder
that likely involves epigenetic factors. To better understand the epigenetic state associated …
that likely involves epigenetic factors. To better understand the epigenetic state associated …
DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
G Shireby, EL Dempster, S Policicchio… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …
DNA methylation signature of human hippocampus in Alzheimer's disease is linked to neurogenesis
M Altuna, A Urdánoz-Casado… - Clinical …, 2019 - Springer
Background Drawing the epigenome landscape of Alzheimer's disease (AD) still remains a
challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD …
challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD …
Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease
Background Alzheimer's disease affects~ 13% of people in the United States 65 years and
older, making it the most common neurodegenerative disorder. Recent work has identified …
older, making it the most common neurodegenerative disorder. Recent work has identified …
Epigenome-wide association study of Alzheimer's disease replicates 22 differentially methylated positions and 30 differentially methylated regions
QS Li, Y Sun, T Wang - Clinical epigenetics, 2020 - Springer
Background Growing evidence shows that epigenetic modifications play a role in
Alzheimer's disease (AD). We performed an epigenome-wide association study (EWAS) to …
Alzheimer's disease (AD). We performed an epigenome-wide association study (EWAS) to …
A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex
Epigenome-wide association studies of Alzheimer's disease have highlighted
neuropathology-associated DNA methylation differences, although existing studies have …
neuropathology-associated DNA methylation differences, although existing studies have …
Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex
Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset
Alzheimer's disease (LOAD), but little has been done on a genome-wide scale to identify …
Alzheimer's disease (LOAD), but little has been done on a genome-wide scale to identify …
Promoter DNA hypermethylation–implications for Alzheimer's disease
Recent methylome-wide association studies (MWAS) in humans have solidified the concept
that aberrant DNA methylation is associated with Alzheimer's disease (AD). We summarize …
that aberrant DNA methylation is associated with Alzheimer's disease (AD). We summarize …
Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease
Background Alzheimer's disease is a progressive neurodegenerative disorder that is
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …
Alzheimer's disease-associated (hydroxy) methylomic changes in the brain and blood
R Lardenoije, JAY Roubroeks, E Pishva, M Leber… - Clinical …, 2019 - Springer
Abstract Background Late-onset Alzheimer's disease (AD) is a complex multifactorial
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …