Early embryo development constitutes a unique opportunity to study acquisition of
epigenetic marks, including histone methylation. This study investigates the in vivo function …

Embryo development proceeds from a cascade of gene activation and repression events
controlled by epigenetic modifications of DNA and histones. Little is known about epigenetic …

Background Multicellular organisms require precise gene regulation during ontogeny, and
epigenetic modifications, such as DNA methylation and histone modification, facilitate this …

DNA methylation and histone modifications are epigenetic marks implicated in the complex
regulation of vertebrate embryogenesis. The cross-talk between DNA methylation and …

Previous studies in Xenopus have shown that forced expression of Nodal signaling can
change ectodermal cells to a mesodermal fate by the early gastrula stage, suggesting …

Background Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in
zebrafish and is a period of extensive chromatin remodeling. Genome-scale gametic …

An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs
essential for cellular function. The genome also harbors cis-acting non-coding sequences …

A hallmark of anamniote vertebrate development is a window of embryonic transcription-
independent cell divisions before onset of zygotic genome activation (ZGA). Chromatin …

The regulated removal of the gene-silencing epigenetic mark, trimethylation of lysine 27 of
histone H3 (H3K27me3), has been shown to be critical for tissue-specific activation of …

Histone methylation patterns are important epigenetic regulators of mammalian
development, notably through stem cell identity maintenance by chromatin remodeling and …