Abstract Lysine-specific demethylase 1 (Lsd1) is associated with transcriptional coregulation
via the modulation of histone methylation. The expression pattern and function of zebrafish …

DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause
silencing of tumor-related genes in cancer. The development of drugs that target these …

The role of DNA methylation in gene inactivation has been studied extensively in vertebrates
but it is not clear whether it serves similar functions in other organisms. We devised a novel …

Neural induction is the initial event of nervous system development during which part of the
ectoderm is specified to become the embryonic neural plate. The biological roles of histone …

Epigenetic modifications undergo drastic erasure and reestablishment after fertilization. This
reprogramming is required for proper embryonic development and cell differentiation. In …

Polycomb group (PcG) proteins are essential regulators of epigenetic gene silencing and
development. The PcG protein enhancer of zeste homolog 2 (Ezh2) is a key component of …

Heterochromatin marks such as H3K9me3 undergo global erasure and re-establishment
after fertilization, and the proper reprogramming of H3K9me3 is essential for early …

5-methylcytosine (5mC) is the best understood DNA modification and is generally believed
to be associated with repression of gene expression. Over the last decade, sequentially …

Background: Lysine demethylase 4C (KDM4C) is a nuclear protein that is essential for
histone modification and acts as an important regulator of several transcription factors …

Setd2 is the only enzyme that catalyzes histone H3 lysine 36 trimethylation (H3K36me3) on
virtually all actively transcribed protein-coding genes, and this mechanism is evolutionarily …