Zebrafish embryos are an exceptional system for studying vertebrate development.
Historically, studies using zebrafish to uncover key players in developmentally regulated …

Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To better understand, we determined DNAme profiles of zebrafish …

Trimethylation of lysine 27 on histone 3 (H3K27me3) by the Polycomb repressive complex 2
(PRC2) contributes to localized and inherited transcriptional repression. Kdm6b (Jmjd3) is a …

DNA methylation, a well-studied epigenetic mark, is important for gene regulation in
adulthood and for development. Using genetic and epigenetic approaches, the present …

Extensive and dynamic chromatin remodeling occurs after fertilization, including DNA
methylation and histone modifications. These changes underlie the transition from gametic …

The influence of histone amino-terminal covalent modifications on gene regulation has
drawn intense research efforts in recent years. It is now clear that activating and inactivating …

The de novo DNA methyltransferase DNMT3B functions in establishing DNA methylation
patterns during development. DNMT3B missense mutations cause immunodeficiency …

Methylation of histone H3 Lys 9 and Lys 27 (H3K9 and H3K27) is associated with
transcriptional silencing. Here we show that KDM7, a JmjC domain-containing protein …

Background Enhancers, not promoters, are the most dynamic in their DNA methylation
status throughout development and differentiation. Generally speaking, enhancers that are …

During the process of embryonic development in mammals, epigenetic modifications must
be erased and reconstructed. In particular, the trimethylation of histone 3 lysine 27 …