Background Enhancers, not promoters, are the most dynamic in their DNA methylation
status throughout development and differentiation. Generally speaking, enhancers that are …

While increasing evidence indicates the important function of histone methylation during
development, how this process influences cardiac development in vertebrates has not been …

Two techniques were used to analyze global genomic 5-methyl cytosine methylation at
CCGG sites of medaka embryo DNA. DNA was labeled by incorporation of microinjected …

Histone lysine methylation is important in early zebrafish development; however, the role of
histone arginine methylation in this process remains unclear. H3R2me2a, generated by …

During early postnatal life, extensive changes in gene expression occur concomitantly in
multiple major organs, indicating the existence of a common core developmental genetic …

Background Cell fate decisions are governed by interactions between sequence‐specific
transcription factors and a dynamic chromatin landscape. Zebrafish offer a powerful system …

Deazaneplanocin A (DzNep), a global histone methylation inhibitor, has attracted significant
interest in epigenetic research in recent years. The molecular mechanism of action and the …

The vertebrate body plan and organs are shaped during a conserved embryonic phase
called the phylotypic stage. However, the mechanisms that guide the epigenome through …

DNA methylation in mammals is highly dynamic during germ cell and preimplantation
development but is relatively static during the development of somatic tissues. 5 …

The vertebrate body plan and organs are shaped during a conserved embryonic phase
called the phylotypic stage. However, the mechanisms that guide the epigenome through …