The neural crest is a multipotent stem cell-like population that is induced during gastrulation,
but only acquires its characteristic morphology, migratory ability, and gene expression …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …

This new volume of Current Topics in Developmental Biology covers epigenetics and
development, with contributions from an international board of authors. The chapters provide …

Post‐translational modification of the histone plays important roles in epigenetic regulation
of various biological processes. Among the identified histone methyltransferases (HMT …

Histone modifications influence the interactions of transcriptional regulators with chromatin.
Studies in embryos and embryonic stem (ES) cells have uncovered histone modification …

Background Chromatin epigenetics participate in control of gene expression during
metazoan development. DNA methylation and post-translational modifications (PTMs) of …

Background Uncovering epigenetic states by chromatin immunoprecipitation and microarray
hybridization (ChIP-chip) has significantly contributed to the understanding of gene …

DNA methylation constitutes an important epigenetic factor in the control of genetic
information. In this study, we analyzed expression of the DNA methyltransferase gene and …

KDM2A is a histone demethylase associated with transcriptional silencing, however very
little is known about its in vivo role in development and disease. Here we demonstrate that …

Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To understand this process, we determined the DNA methylation (DNAme) …