Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …

The establishment of synaptic plasticity and long-term memory requires lasting cellular and
molecular modifications that, as a whole, must endure despite the rapid turnover of their …

Learning and memory are two of the fundamental cognitive functions that confer us the
ability to accumulate knowledge from our experiences. Although we use these two mental …

DNA methylation was traditionally viewed as a static mechanism required during cell fate
determination. This view has been challenged and it is now accepted that DNA methylation …

Although long-lasting behavioral memories have long been thought to require equally
persistent molecular changes, little is known about the biochemical underpinnings of …

A behavioral memory's lifetime represents multiple molecular lifetimes, suggesting the
necessity for a self-perpetuating signal. One candidate is DNA methylation, a transcriptional …

Adult neurogenesis enables the life‐long addition of functional neurons to the hippocampus
and is regulated by both cell‐intrinsic molecular programs and behavioral activity. De novo …

DNA methylation was once considered to be a static epigenetic modification whose primary
function was restricted to directing the development of cellular phenotype. However, it is now …

Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in
learning and memory. Methylation of cytosine nucleotides has historically been considered …

The ability to form memories is a prerequisite for an organism's behavioral adaptation to
environmental changes. At the molecular level, the acquisition and maintenance of memory …