Background Cell fate decisions are governed by interactions between sequence‐specific
transcription factors and a dynamic chromatin landscape. Zebrafish offer a powerful system …

Early animal development is characterized by intense reorganization of the embryonic
genome, including large-scale changes in chromatin structure and in the DNA and histone …

Currently, the dynamic accessible elements that determine regulatory programs responsible
for the unique identity and function of each cell type during zebrafish embryogenesis lack …

DNA accessibility of cis-regulatory elements (CREs) dictates transcriptional activity and
drives cell differentiation during development. While many genes regulating embryonic …

Chromatin accessibility plays a critical role in the regulation of cell fate decisions. Although
gene expression changes have been extensively profiled at the single-cell level during early …

The generation of complex organisms requires that an initial population of cells with
identical gene expression profiles can adopt different cell fates during development by …

Vertebrate embryogenesis is a remarkable process, during which numerous cell types of
different lineages arise within a short time frame. An overwhelming challenge to understand …

The recruitment of chromatin regulators and the assignment of chromatin states to specific
genomic loci are pivotal to cell fate decisions and tissue and organ formation during …

Chromatin architecture mapping in 3D formats has increased our understanding of how
regulatory sequences and gene expression are connected and regulated in a genome. The …

The complex processes necessary for embryogenesis require a gene regulatory network
that is complex and systematic. Gene expression regulates development and …