A change in chromosome number that is not the exact multiple of the haploid karyotype is
known as aneuploidy. This condition interferes with growth and development of an organism …

Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date,
aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also …

Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …

Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant
cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of …

Numeric aberrations in chromosomes, referred to as aneuploidy, is commonly observed in
human cancer. Whether aneuploidy is a cause or consequence of cancer has long been …

The role of aneuploidy in carcinogenesis has long been debated. We argue here that
aneuploid genomes are naturally more susceptible to the types of chromosome …

Aneuploidy or chromosome imbalance is the most massive genetic abnormality of cancer
cells. It used to be considered the cause of cancer when it was discovered more than 100 …

Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans
carrying an aberrant karyotype. Yet, whether or how this condition contributes to …

The many complex phenotypes of cancer have all been attributed to “somatic mutation.”
These phenotypes include anaplasia, autonomous growth, metastasis, abnormal cell …

Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells.
In humans, aneuploidy is associated with various pathologies, including cancer, which …