Aneuploidy, the presence of an extra or missing chromosome, is the most frequent cause of
mental retardation and pregnancy loss in our species. Studies can be divided into those of …

Whole-chromosome copy number alterations, also known as aneuploidy, are associated
with adverse consequences in most cells and organisms. However, high frequencies of …

Although nearly all mammalian species are diploid, whole-genome duplications occur in
select mammalian tissues as part of normal development. Such programmed …

When cells in our body change their genome and develop into cancer, we blame it on
genome instability. When novel species conquer inhospitable environments, we credit it to …

Human cancers harbor great numbers of genomic alterations. One of the most common
alterations is aneuploidy, an imbalance at the chromosome level. Some aneuploid cancer …

Polyploidy, an increased number of chromosome sets, is a surprisingly common
phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in …

Whole chromosome and arm-level copy number alterations occur at high frequencies in
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …

Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in
chromosome copy number have been proposed to drive disease by modulating the dosage …

Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Unusually large cancer cells with abnormal nuclei have been documented in the cancer
literature since 1858. For more than 100 years, they have been generally disregarded as …