In mammalian sexual reproduction, each parent contributes a haploid set of chromosomes
to the offspring. It is usually believed that these two haploid sets are on the whole equivalent …

Publisher Summary This chapter presents a methylation mosaic model for mammalian
genome imprinting. This model predicts that the paternally transmitted allele at some loci will …

ABSTRACT A number of transgenes in the mouse show variation in methylation and
expression phenotypes dependent on parental transmission. It appears that there exist at …

We have examined the relative methylation levels of several dispersed repeated and low-
copy-number gene sequences during gametogenesis and early embryogenesis. Southern …

Genomic imprinting in mammals is thought to be mediated by differences in the methylation
level of cytosine residues in the genome. These differences in DNA methylation are thought …

Publisher Summary The evident specialization of maternal and paternal genomes in
mammals has been defined as genomic imprinting and is thought to arise during …

Epigenetic modifications such as DNA methylation and alterations to chromatin structure
have been proposed as hallmarks of imprinting in somatic cells after fertilization. In the germ …

In mammals, the maternal and the paternal genome are not functionally equivalent and are
both required for embryonic and postnatal development. The genome is organised …

Genomic imprinting is an epigenetic phenomenon by which the two parental alleles of a
gene are differentially expressed. Although the function of genomic imprinting is not clear, it …

It has recently been shown that functional differences between parental genomes in the
developing mouse can be attributed to germ-line specific modifications (imprinting) of certain …