Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …

We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the
genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal …

Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating
consequences on the developing child. Genomic studies have revealed four distinct …

Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups.
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of …

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the
genetic alterations in this tumor type, we searched for copy number alterations using high …

Medulloblastoma is currently subclassified into distinct DNA methylation
subgroups/subtypes with particular clinico-molecular features. Using RNA sequencing (RNA …

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or
medulla/brain stem. It is the most common malignant brain tumour in children, and shows …

Epigenetics is the process by which gene expression is regulated by events other than
alterations of the genome. This includes DNA methylation, histone modifications, chromatin …

Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …

Medulloblastomas exhibit an array of diverse cytogenetic abnormalities. To evaluate the
significance of epigenetic rather than genetic lesions in medulloblastomas and other …