The bright and dark side of DNA methylation: A matter of balance

M Borchiellini, S Ummarino, A Di Ruscio - Cells, 2019 - mdpi.com
DNA methylation controls several cellular processes, from early development to old age,
including biological responses to endogenous or exogenous stimuli contributing to disease …

[PDF][PDF] New insights on the role of DNA methylation from a global view

K Meier, F Recillas-Targa - Front Biosci (Landmark Ed), 2017 - article.imrpress.com
In mammals, DNA methylation is a crucial epigenetic modification with key functions during
development. Cellular processes that are regulated by DNA methylation comprise X …

Genome-wide distribution of DNA methylation at single-nucleotide resolution

E Wong, CL Wei - Progress in Molecular Biology and Translational …, 2011 - Elsevier
DNA methylation, a well-known epigenetic modification in mammalian genomes, is
important for development and health. Dysregulation of DNA methylation can cause …

DNA methylation in development and human disease

S Gopalakrishnan, BO Van Emburgh… - … Molecular Mechanisms of …, 2008 - Elsevier
DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns

C Marchal, B Miotto - Journal of cellular physiology, 2015 - Wiley Online Library
DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

DNA demethylation pathways: recent insights

C Li - Genetics & Epigenetics, 2013 - journals.sagepub.com
DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell
differentiation. Until recently, it was still unclear how unmethylated regions in mammalian …

The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Origin and mechanisms of DNA methylation dynamics in cancers

H Easwaran, SB Baylin - The DNA, RNA, and Histone Methylomes, 2019 - Springer
DNA methylation is a key epigenetic mark in the heritable regulation of gene expression,
with important roles in normal development and disease. Genomewide alterations in DNA …

Making it or breaking it: DNA methylation and genome integrity

A Sriraman, TK Debnath, B Xhemalce… - Essays in …, 2020 - portlandpress.com
Cells encounter a multitude of external and internal stress-causing agents that can ultimately
lead to DNA damage, mutations and disease. A cascade of signaling events counters these …

Diverse and dynamic DNA modifications in brain and diseases

MJ Armstrong, Y Jin, EG Allen… - Human molecular …, 2019 - academic.oup.com
DNA methylation is a class of epigenetic modification essential for coordinating gene
expression timing and magnitude throughout normal brain development and for proper brain …