DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during
differentiation of self-renewing stem cells. However, whether these changes are the cause or …

Hematopoietic stem cells give rise to all blood cells in a differentiation process that involves
widespread epigenome remodeling. Here we present genome-wide reference maps of the …

DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and
in the commitment to the lymphoid or myeloid lineages. Using purified CD34+ hematopoietic …

DNA methylation has been implicated as an epigenetic component of mechanisms that
stabilize cell-fate decisions. Here, we have characterized the methylomes of human female …

DNA methylation is an essential epigenetic mark that is required for normal development.
Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment …

The functional potential of hematopoietic stem cells (HSCs) declines during aging, and in
doing so, significantly contributes to hematopoietic pathophysiology in the elderly. To …

Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies,–and clonal hematopoiesis …

DNA methylation is essential for development and in diverse biological processes. The DNA
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …

During hematopoiesis, a unique hematopoietic stem cell (HSC) from the bone marrow gives
rise to a subset of mature blood cells that directs all the immune responses. Recent studies …

Global mechanisms defining the gene expression programs specific for hematopoiesis are
still not fully understood. Here, we show that promoter DNA demethylation is associated with …