The selective estrogen receptor modulator, tamoxifen, has been shown to reduce DNA
methylation at Insulin-like growth factor 2/H19 differentially methylated region (Igf2/H19 …

Estrogen, through its receptors, regulates various aspects of spermatogenesis and male
fertility. To understand the roles of estrogen receptors (ERα and ERβ) in male fertility, we …

OBJECTIVE: To determine the effect of tamoxifen treatment on global and insulin-like growth
factor 2-H19 imprinting control region (Igf2-H19 ICR)-specific DNA methylation in rat …

Igf2, an imprinted gene that is paternally expressed in embryos, encodes an embryonic
growth factor. An important regulator of Igf2 expression is methylation of the H19 …

Estrogen receptors (ESR1 and ESR2) play crucial roles in various processes during
spermatogenesis. To elucidate individual roles of ESRs in male fertility, we developed in …

Aim A growing body of evidence pointed correlation between insulin‐resistance,
testosterone level and infertility, but there is scarce information about mechanisms. The aim …

Given the higher risk of developing imprinting disorders in assisted reproductive technology
(ART)-conceived children, we hypothesized that ART may affect DNA methylation of the …

Background In children, recombinant human growth hormone (rhGH) therapy for treatment
of short stature has raised concerns of the early onset of puberty. Puberty is initiated by the …

Introduction Insulin-like growth factor 2 (IGF2) mRNA has been found in human and mouse
spermatozoa. It is currently unknown whether the IGF2 protein is expressed in human …

The mechanism controlling tissue-specific expression of estrogen receptor 1 (ESR1) is
unclear. In other genes, DNA methylation of a region called the tissue-dependent and …