Methyl CpG‐binding proteins and transcriptional repression
PA Wade - Bioessays, 2001 - Wiley Online Library
Since its discovery, methylation of DNA in mammalian cells has been correlated with
transcriptional repression and with specialized chromatin structures. Recently, considerable …
transcriptional repression and with specialized chromatin structures. Recently, considerable …
Methyl CpG binding proteins: coupling chromatin architecture to gene regulation
PA Wade - Oncogene, 2001 - nature.com
A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …
years. Recently, substantial progress has been reported in the search for proteins that …
Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1
N Fujita, N Shimotake, I Ohki, T Chiba… - … and cellular biology, 2000 - Am Soc Microbiol
MBD1 is a mammalian protein that binds symmetrically methylated CpG sequences and
regulates gene expression in association with DNA methylation. This protein possesses a …
regulates gene expression in association with DNA methylation. This protein possesses a …
Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
T Clouaire, JI de Las Heras, C Merusi… - Nucleic acids …, 2010 - academic.oup.com
MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to
repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms …
repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms …
Active repression of methylated genes by the chromosomal protein MBD1
HH Ng, P Jeppesen, A Bird - Molecular and cellular biology, 2000 - Taylor & Francis
MBD1 belongs to a family of mammalian proteins that share a methyl-CpG binding domain.
Previous work has shown that MBD1 binds to methylated sites in vivo and in vitro and can …
Previous work has shown that MBD1 binds to methylated sites in vivo and in vitro and can …
DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG
RJ Klose, SA Sarraf, L Schmiedeberg, SM McDermott… - Molecular cell, 2005 - cell.com
DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …
that repress transcription through recruitment of corepressors that modify chromatin. To …
Methyl‐CpG‐binding proteins: Targeting specific gene repression
E Ballestar, AP Wolffe - European journal of biochemistry, 2001 - Wiley Online Library
CpG methylation, the most common epigenetic modification of vertebrate genomes, is
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …
Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains
HF Jørgensen, I Ben-Porath… - Molecular and cellular …, 2004 - Am Soc Microbiol
MBD1 is a vertebrate methyl-CpG binding domain protein (MBD) that can bring about
repression of methylated promoter DNA sequences. Like other MBD proteins, MBD1 …
repression of methylated promoter DNA sequences. Like other MBD proteins, MBD1 …
The MBD protein family—reading an epigenetic mark?
A Dhasarathy, PA Wade - Mutation Research/Fundamental and Molecular …, 2008 - Elsevier
A family of proteins conserved throughout the eukaryotic lineage is characterized by the
presence of a common sequence motif—the methyl-CpG-binding domain, or MBD. This …
presence of a common sequence motif—the methyl-CpG-binding domain, or MBD. This …
Engineering a high-affinity methyl-CpG-binding protein
HF Jørgensen, K Adie, P Chaubert… - Nucleic acids …, 2006 - academic.oup.com
Core members of the MBD protein family (MeCP2, MBD1, MBD2 and MBD4) share a methyl-
CpG-binding domain that has a specific affinity for methylated CpG sites in double-stranded …
CpG-binding domain that has a specific affinity for methylated CpG sites in double-stranded …
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