Since its discovery, methylation of DNA in mammalian cells has been correlated with
transcriptional repression and with specialized chromatin structures. Recently, considerable …

A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …

MBD1 is a mammalian protein that binds symmetrically methylated CpG sequences and
regulates gene expression in association with DNA methylation. This protein possesses a …

MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to
repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms …

MBD1 belongs to a family of mammalian proteins that share a methyl-CpG binding domain.
Previous work has shown that MBD1 binds to methylated sites in vivo and in vitro and can …

DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …

CpG methylation, the most common epigenetic modification of vertebrate genomes, is
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …

A family of proteins conserved throughout the eukaryotic lineage is characterized by the
presence of a common sequence motif—the methyl-CpG-binding domain, or MBD. This …

MBD1 is a vertebrate methyl-CpG binding domain protein (MBD) that can bring about
repression of methylated promoter DNA sequences. Like other MBD proteins, MBD1 …

Core members of the MBD protein family (MeCP2, MBD1, MBD2 and MBD4) share a methyl-
CpG-binding domain that has a specific affinity for methylated CpG sites in double-stranded …