Background: Sensitive, specific blood-based tests are difficult to develop unless steps are
taken to maximize performance characteristics at every stage of marker discovery and …

Background Specific genes are methylated with high frequency in colorectal neoplasia, and
may leak into blood. Detection of multiple methylated DNA biomarkers in blood may improve …

Background Early detection plays an essential role to reduce colorectal cancer (CRC)
mortality. While current screening methods suffer from poor compliance, liquid biopsy-based …

Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide, and late
stages (III-IV) in particular have low 5-year survival rates. Stage shifting by CRC screening …

OBJECTIVES While promoter hypermethylation is a common molecular alteration of human
colorectal cancer that could be detected in the bloodstream, we tested the feasibility of …

In peripheral blood, cell-free methylated DNA has been reported to be a useful biomarker of
noninvasive blood screening for the detection of colorectal cancer (CRC), including the …

Colorectal cancer (CRC) screening rates are currently suboptimal. Blood‐based screening
could improve rates of earlier detection for CRC and adenomatous colorectal polyps. In this …

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

Background There is an increasing demand for accurate biomarkers for early non-invasive
colorectal cancer detection. We employed a genome-scale marker discovery method to …

Background Colorectal cancer (CRC) is one of the most common cancers in the western
world. Screening is an efficient method of reducing cancer-related mortality. Molecular …