Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease

N Lafontaine, CJ Shore, PJ Campbell… - The Journal of …, 2024 - academic.oup.com
Context Autoimmune thyroid disease (AITD) includes Graves disease (GD) and Hashimoto
disease (HD), which often run in the same family. AITD etiology is incompletely understood …

DNA methylation in autoimmune thyroid disease

N Lafontaine, SG Wilson… - The Journal of Clinical …, 2023 - academic.oup.com
Graves disease and Hashimoto disease form part of the spectrum of autoimmune thyroid
disease (AITD), to which genetic and environmental factors are recognized contributors …

Genome-wide DNA methylation pattern in whole blood of patients with Hashimoto thyroiditis

Z Zhou, J Liu, Y Chen, B Ren, S Wan, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Background Hashimoto thyroiditis (HT), a prevalent autoimmune disorder, is not yet
thoroughly understood, especially when it comes to the influence of epigenetics in its …

Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid …

Y Arakawa, M Watanabe, N Inoue… - Clinical & …, 2012 - academic.oup.com
To clarify the association between factors regulating DNA methylation and the prognosis of
autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in …

Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling

M Limbach, M Saare, L Tserel, K Kisand, T Eglit… - Journal of …, 2016 - Elsevier
Abstract In Graves' disease (GD), a combination of genetic, epigenetic and environmental
factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic …

Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9

A Weihs, L Chaker, TC Martin, KVE Braun… - Thyroid, 2023 - liebertpub.com
Background: Thyroid hormones play a key role in differentiation and metabolism and are
known regulators of gene expression through both genomic and epigenetic processes …

Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L

N Lafontaine, PJ Campbell… - The Journal of …, 2021 - academic.oup.com
Context Circulating concentrations of free triiodothyronine (fT3), free thyroxine (fT4), and
thyrotropin (TSH) are partly heritable traits. Recent studies have advanced knowledge of …

DNA Methylation Patterns in the HLA-DPB1 and PDCD1LG2 Gene Regions in Patients with Autoimmune Thyroiditis from Different Water Iodine Areas

S Wan, L Liu, B Ren, M Qu, H Wu, W Jiang, X Wang… - Thyroid, 2021 - liebertpub.com
Background: Epigenetic disorders play an important role in the pathogenesis of autoimmune
thyroiditis (AIT). Therefore, the study of the possible role of DNA methylation in AIT is of great …

Genome‑wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism

J Luo, X Wang, L Yuan, L Guo - Clinical Epigenetics, 2021 - Springer
Background Type 2 diabetes mellitus (T2DM) and hypothyroidism are two common
endocrine diseases and the phenomenon that the prevalence of diabetes-related …

Methylation levels of the TNFA gene are different between Graves' and Hashimoto's diseases and influenced by the TNFA polymorphism

E Morita, M Watanabe, N Inoue, H Hashimoto… - …, 2018 - Taylor & Francis
Graves' disease (GD) and Hashimoto's disease (HD) are different pathological types of
autoimmune thyroid diseases (AITDs). However, the epigenetic differences between these …