Histone arginine methylation has emerged as an important histone modification involved in
gene regulation. Protein arginine methyltransferase (PRMT) 4 and 5 have been shown to …

Prmt5, an arginine methyltransferase, has multiple roles in germ cells, and possibly in
pluripotency. Here we show that loss of Prmt5 function is early embryonic-lethal due to the …

Human pluripotent stem cells (PSCs) are critical in vitro tools for understanding mechanisms
that regulate lineage differentiation in the human embryo as well as a potentially unlimited …

Protein arginine methylation is a posttranslational modification catalyzed by protein arginine
methyltransferases (PRMTs), which play critical roles in many biological processes. To date …

Arginine methylation is one of the most important post-translational modifications which is
catalyzed by protein arginine methyltransferases (PRMTs). Previous studies have …

Summary Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation
of histone H3 at arginine 2 (H3R2me2a). This mark has been reported to associate with …

CARM1 is a protein arginine methyltransferase (PRMT) that acts as a coactivator in a
number of transcriptional programs. CARM1 orchestrates this coactivator activity in part by …

Arginine methylation governs important cellular processes that impact growth and
proliferation, as well as differentiation and development. Through their ability to catalyze …

In mammals, germ cells undergo massive epigenetic remodeling during fetal development.
However, the physiological functions of epigenetic modification in germ cell development …

PRMT1 is a histone methyltransferase that methylates Arg3 on histone H4. When we used
siRNA to knock down PRMT1 in an erythroid cell line, it resulted in nearly complete loss of …