Hooked! Modeling human disease in zebrafish

C Santoriello, LI Zon - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …

Zebrafish models in translational research: tipping the scales toward advancements in human health

JB Phillips, M Westerfield - Disease models & mechanisms, 2014 - journals.biologists.com
Advances in genomics and next-generation sequencing have provided clinical researchers
with unprecedented opportunities to understand the molecular basis of human genetic …

Of fish and men: using zebrafish to fight human diseases

J Ablain, LI Zon - Trends in cell biology, 2013 - cell.com
Long restricted to the field of developmental biology, the use of the zebrafish (Danio rerio)
has extended to the study of human pathogenesis. Fostered by the rapid adaptation of new …

Animal models of human disease: zebrafish swim into view

GJ Lieschke, PD Currie - Nature Reviews Genetics, 2007 - nature.com
Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

[PDF][PDF] Zebrafish: from disease modeling to drug discovery

AL Rubinstein - Current Opinion in Drug Discovery and Development, 2003 - Citeseer
The study of zebrafish, a leading model organism for developmental biology, is rapidly
expanding to include human disease. Zebrafish models based on known disease …

Beyond the zebrafish: diverse fish species for modeling human disease

M Schartl - Disease models & mechanisms, 2014 - journals.biologists.com
In recent years, zebrafish, and to a lesser extent medaka, have become widely used small
animal models for human diseases. These organisms have convincingly demonstrated the …

[PDF][PDF] The zebrafish as a model system for human disease

AC Ward, GJ Lieschke - Front Biosci, 2002 - article.imrpress.com
[Frontiers in Bioscience 7, d827-833, April 1, 2002] 827 THE ZEBRAFISH AS A MODEL
SYSTEM FOR HUMAN DISEASE Alister C. Ward1,2 a Page 1 [Frontiers in Bioscience 7 …

Think small: zebrafish as a model system of human pathology

JR Goldsmith, C Jobin - BioMed Research International, 2012 - Wiley Online Library
Although human pathologies have mostly been modeled using higher mammal systems
such as mice, the lower vertebrate zebrafish has gained tremendous attention as a model …

Zebrafish: bridging the gap between development and disease

A Dodd, PM Curtis, LC Williams… - Human molecular …, 2000 - academic.oup.com
The zebrafish has been the model of choice amongst developmental biologists for many
years. This small freshwater species offers many advantages to the study of organ and …

Zebrafish models of human disease: gaining insight into human disease at ZFIN

YM Bradford, S Toro, S Ramachandran, L Ruzicka… - ILAR …, 2017 - academic.oup.com
Abstract The Zebrafish Model Organism Database (ZFIN; https://zfin. org) is the central
resource for genetic, genomic, and phenotypic data for zebrafish (Danio rerio) research …