DNA methylation is a mechanism of epigenetic regulation that is common to all vertebrates.
Functional studies underscore its relevance for tissue homeostasis, but the global dynamics …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

Hematopoietic stem cells give rise to all blood cells in a differentiation process that involves
widespread epigenome remodeling. Here we present genome-wide reference maps of the …

DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and
in the commitment to the lymphoid or myeloid lineages. Using purified CD34+ hematopoietic …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during
differentiation of self-renewing stem cells. However, whether these changes are the cause or …

Global mechanisms defining the gene expression programs specific for hematopoiesis are
still not fully understood. Here, we show that promoter DNA demethylation is associated with …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is an essential epigenetic mark that is required for normal development.
Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment …