A best evidence topic in cardiac surgery was written according to a structured protocol. The
question addressed was: what dose of tranexamic acid is most effective and safe for adult …

Tranexamic acid reduces blood loss and transfusion requirements with no significant
thrombotic adverse effects. Postoperative seizures have been seen in cardiac surgical …

Background It is unclear whether high-dose regimens of tranexamic acid in cardiac surgery
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …

Background: The optimal dose of tranexamic acid (TA) is still an issue. The authors
compared two doses of TA during cardiac surgery in a multicenter, double-blinded …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Introduction Bleeding during cardiac surgery is associated with increased morbidity and
mortality. Tranexamic acid is an antifibrinolytic with proven efficacy in major surgeries …

Background Many different doses and administration schemes have been proposed for the
use of the antifibrinolytic drug tranexamic acid during cardiac surgery. This study evaluated …

Objective (s): The authors have developed an alternative dosing schedule for tranexamic
acid that incorporates the effects of renal function on tranexamic acid concentrations. The …

We conducted a study to assess pharmacokinetics of high‐dose tranexamic acid for 24 h
after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary …

Background The efficacy of tranexamic acid (TXA) to reduce perioperative blood loss and
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …