Mutations in the complement regulators factor H, membrane cofactor protein (MCP), and
factor I are associated with atypical hemolytic uremic syndrome (aHUS, MIM 235400) …

Hemolytic uremic syndrome (HUS) is a very rare disease (two cases per year per 1 million
population) but represents the most common cause of acute renal failure in young children …

Introduction Comprehensive genetic analysis is essential to clinical care of patients with
atypical haemolytic uremic syndrome (aHUS) to reinforce diagnosis, and to guide treatment …

The efficiency of the complement system as an innate immune defense mechanism depends
on a fine control that restricts its action to pathogens and prevents non-specific damage to …

Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement
regulation. Disease-associated mutations have been described in the genes encoding the …

Hemolytic uremic syndrome (HUS) is a rare, life-threatening disease characterized by
thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The atypical …

Hemolytic uremic syndrome (HUS) is a systemic disease characterized by damage to
endothelial cells, erythrocytes and kidney glomeruli. A “typical” form of HUS follows …

Atypical hemolytic uremic syndrome (aHUS) associates with complement dysregulation
caused by mutations and polymorphisms in complement activators and regulators. However …

Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic
anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the …

Several abnormalities in complement genes reportedly contribute to atypical hemolytic
uremic syndrome (aHUS), but incomplete penetrance suggests that additional factors are …