Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …

Epigenetics can be defined as the study of heritable changes in gene expression without
alteration of the DNA sequence itself. This means that epigenetic variants are stable …

Epigenetic modifications of DNA such as methylation are important for genome function
during development and in adults. DNA methylation has central importance for genomic …

Several lines of evidence strongly suggest that DNA methylation is involved in embryo
development. Perhaps the most direct evidence comes from experiments with …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …

Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …