Single nucleotide polymorphisms (SNPs) in genes involved in thyroid hormone metabolism
may affect thyroid hormone bioactivity. We investigated the occurrence and possible effects …

Serum thyroid parameters show substantial inter-individual variability, in which genetic
variation is a major factor. Findings in patients with subclinical hyper-and hypothyroidism …

Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …

Graves' disease (GD) is caused by an interplay of genetic factors and environmental
triggers. The major antigen in GD is the thyrotropin receptor (TSHR) on the surface of the …

Graves' disease (GD) is a common autoimmune disease (AID) that shares many of its
susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) …

Summary Objectives The Asp727Glu polymorphism in the TSH receptor (TSHR) gene is
associated with serum TSH levels. However, the proportion of genetic variation accounted …

Mutations arise as a change in the coding sequence of a gene. Point mutations occur when
another replaces one base. Insertions and deletions are the addition and removal of one or …

Genetics play a prominent role in both determination of thyroid hormone and thyrotropin
(TSH) concentrations, and susceptibility to autoimmune thyroid disease. Heritability studies …

Thyrotropin (TSH) receptor (TSHr) mutations have been investigated in relation to Graves'
disease (GD) genetic susceptibility under the hypothesis that a modified antigen may have …

Abstract Effects of thyroid hormones in individual tissues are determined by many factors
beyond their serum levels, including local deiodination and expression and activity of thyroid …