The relationship between localized changes in brain activity and metabolism, and the blood
oxygenation level‐dependent (BOLD) signal used in functional magnetic resonance …

Hypercapnia is often used as vasodilatory challenge in clinical applications and basic
research. In functional magnetic resonance imaging (fMRI), elevated CO2 is applied to …

BACKGROUND AND PURPOSE: The relationship between the local blood oxygen level–
dependent (BOLD) signals caused by neural stimulation (fBOLD) and the global BOLD …

The effect of hypercapnia on the cerebral metabolic rate of oxygen consumption (CMRO2)
remains incompletely understood. This study examined the relationship between …

Neuronal activation results in increases in blood-oxygen-level-dependent (BOLD) signal
increases in magnetic resonance images, increases in cerebral blood flow (CBF), and …

Purpose To examine the regional blood oxygenation level‐dependent (BOLD) signal
response to rapid changes in arterial oxygen tension. Materials and Methods Functional MR …

The blood oxygenation level-dependent (BOLD) contrast mechanism can be modeled as a
complex interplay between CBF, cerebral blood volume (CBV), and CMRO2. Positive BOLD …

The physiological effect of hyperoxia has been poorly characterize d, with studies reporting
conflicting results on the role of hyperoxia as a vasoconstrictor. It is not clear whether …

The blood-oxygenation-level-dependent (BOLD) signal is an indirect hemodynamic signal
that is sensitive to cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral …

Because of the importance of oxidative energetics for cerebral function, extraction of oxygen
consumption (CMRO2) from blood oxygenation level‐dependent (BOLD) signal using multi …