Background Epigenetic markings acquired in early life may have phenotypic consequences
later in development through their role in transcriptional regulation with relevance to the …

Gestational age (GA) and birth weight have been implicated in the determination of long-
term health. It has been hypothesized that changes in DNA methylation may mediate these …

Background DNA methylation has been shown to be associated with adiposity in adulthood.
However, whether similar DNA methylation patterns are associated with childhood and …

Maternal obesity is an important risk factor for childhood obesity and influences the
prevalence of metabolic diseases in offspring. As childhood obesity is influenced by …

Results: No individual methylation sites at birth were associated with obesity or insulin
sensitivity measures at 5 years. DNA methylation in 69 genomic regions at birth was …

Childhood obesity remains an epidemic in the US and worldwide. However, little is
understood regarding the epigenetic basis of obesity in adolescents. To investigate the …

Background DNA methylation is associated with body mass index (BMI), but it is not clear if
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

Maternal obesity is associated with a variety of common diseases in the offspring. One
possible underlying mechanism could be maternal obesity induced alterations in DNA …

Adiposity and obesity result from the interaction of genetic variation and environmental
factors from very early in life, possibly mediated by epigenetic processes. Few Epigenome …