Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in
learning and memory. Methylation of cytosine nucleotides has historically been considered …

Dynamic variations in DNA methylation regulate neuronal gene expression in an experience-
dependent manner. Although DNA methylation has been implicated in synaptic plasticity …

Learning and memory are two of the fundamental cognitive functions that confer us the
ability to accumulate knowledge from our experiences. Although we use these two mental …

Cytosine DNA methylation is a stable epigenetic modification with established roles in
regulating transcription, imprinting, female X-chromosome inactivation, and silencing of …

DNA methylation was traditionally viewed as a static mechanism required during cell fate
determination. This view has been challenged and it is now accepted that DNA methylation …

The role of DNA methylation in brain development is an intense area of research because
the brain has particularly high levels of CpG and mutations in many of the proteins involved …

Adult neurogenesis enables the life‐long addition of functional neurons to the hippocampus
and is regulated by both cell‐intrinsic molecular programs and behavioral activity. De novo …

Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …

Recent observations suggest that DNA methylation plays an important role in memory and
long-term potentiation (LTP) in the hippocampus and is involved in programming the …

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …