Extracellular regulated protein kinase (ERK) pathway activation in astrocytes and neurons
has been reported to be critical for neuropathic pain development after chronic constriction …

Serotonin (5-HT) plays a major yet complex role in modulating spinal nociceptive
transmission as a consequence of the number of 5-HT receptor subtypes. These include the …

Abstract Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT
receptors. The role of 5-HT 5A receptor in neuropathic pain has not previously studied. The …

ABSTRACT Preclinical Research This work was performed to assess the effects of
intrathecal serotonin 2B (5‐HT2B) receptor antagonists in rats with neuropathic pain. With …

In the present study we determined the role of spinal 5-hydroxytriptamine (5-HT) and 5-
HT4/6/7 receptors in the long-term secondary mechanical allodynia and hyperalgesia …

The present study evaluated the possible antiallodynic effect induced by [6]‐gingerol in rats
with L5–L6 spinal nerve ligation (SNL). Moreover, we determined the possible mechanism …

We examined the involvement of spinal 5-HT (5-hydroxytryptamine) receptor 3 (5-HT3R)
and 7 (5-HT7R) as well as the overall role of descending serotonergic projections in the …

Tapentadol is a dual action molecule with mu opioid agonist and norepinephrine (NE)
reuptake blocking activity that has recently been introduced for the treatment of moderate to …

The descending serotonergic pathway, from the brainstem to spinal cord, modulates various
aspects of pain processing. The spinal 5-hydroxytryptamine (5-HT) 1A and 5-HT 2A …

Gabapentinoids are recommended first-line treatments for neuropathic pain. They are
neuronal voltage-dependent calcium channel α2δ-1 subunit ligands and have been …