Antidepressants, such as duloxetine and amitriptyline, are effective for treating patients with
chronic neuropathic pain. Inhibiting norepinephrine and serotonin transporters at …

Etidronate is widely used as a therapeutic agent for osteoporosis. We have recently shown
that intrathecal administration of etidronate into mice produces an analgesic effect against …

Several lines of evidence suggest that descending serotoninergic facilitatory pathways are
involved in neuropathic pain. These pathways may involve 5-HT2A receptors known to play …

Background Currently, medical treatment of inflammatory pain is limited by a lack of safe and
effective therapies. Triptonide (TPN), a major component of Tripterygium wilfordii Hook. f …

There is considerable evidence to support the role of anandamide (AEA), an endogenous
ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects …

To examine the role of the descending serotonergic system in the regulation of spinal
nociceptive processing, the effects of serotonin (5-HT) and selective ligands for 5-HT …

Background Amitriptyline and other tricyclic antidepressants exhibit high affinity binding to N-
methyl-D-aspartate (NMDA) receptors in vitro and inhibit NMDA receptor activation-induced …

Neural plasticity within the spinal nociceptive network may be fundamental to the chronic
nature of neuropathic pain. The relation of growth-associated protein-43 (GAP-43), a protein …

Dexmedetomidine, a selective alpha 2-adrenoceptor (α 2 AR) agonist, has provided
significant analgesia in neuropathic pain. However, its underlying molecular mechanism has …

Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat
chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of …