Mast cells take part of armamentarium immunologic for host defense against parasitic and
bacterial infections. They are derived from bone marrow progenitors and can be activated by …

Melatonin is a molecule endogenously produced in a wide variety of immune cells, including
mast cells (RBL‐2H3). It exhibits immunomodulatory, anti‐inflammatory and anti‐apoptotic …

Literature data indicate a significant immunoregulatory role of melatonin. Melatonin exerts
an effect directly affecting leucocytes bearing specific melatonin receptors or indirectly by …

Melatonin is an indoleamine widely distributed in the evolution that shows a great functional
versatility, playing an important role as a transmitter of photoperiodic information and …

Earlier studies have shown that the pineal hormone melatonin activates human monocytes.
It is reported here that melatonin induces the secretion of IL-1, IL-6, and TNF in fresh and 1 …

Melatonin has been proposed as regulating the immune system by affecting cytokine
production in immunocompetent cells, enhancing the production of several T helper (Th) 1 …

It has been historically assumed that the pineal gland is the major source of melatonin (N‐
acetyl‐5‐methoxytryptamine) in vertebrates. Melatonin plays a central role in fine‐tuning …

Melatonin seems to be an important stimulatory factor of the immune system. This
indolamine is capable of inducing activation of leukocytes. Tissue leukocyte infiltration is a …

The pineal hormone melatonin exhibits immunomodulatory activity well documented in
mammals and birds. The mechanism of melatonin action within the immune system is …

Human lymphocytes have recently been described as an important physiological source of
melatonin (N‐acetyl‐5‐methoxytryptamine), which could be involved in the regulation of the …